Anti-NPC2 antibody
Specifications
| Product Cat#: | AB-06-3184 |
| Product type: | Primary antibody |
| Antigen: | NPC2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Niemann Pick C2 20-80/151 |
| Species immunized: | Rabbit |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-2000) |
| Reactivity: | Human, Mouse, Rat, Cow, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | EDDM1 |
| Niemann Pick C2 | |
| Epididymal protein 1 | |
| Epididymal secretory protein | |
| Epididymal secretory protein E1 | |
| Human epididymis-specific protein 1 | |
| Niemann-Pick disease type C2 | |
| Niemann-Pick disease type C2 protein | |
| NPC2 | |
| NPC2_HUMAN |
靶标信息
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
产品来源
洱畔科技实验室
