Anti-TEAD2 antibody
产品特性
| Product Cat#: | AB-07-2169 |
| Product type: | Primary antibody |
| Antigen: | TEAD2 |
| Immunogen: | The antiserum was produced against synthesized peptide derived from internal of human TEAD2. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunocytochemistry (1:50-1:100); ELISA (1:4500); Immunofluorescence (1:100-1:500) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodiumazide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | TEA domain family member 2; TEAD-2 |
靶标信息
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC ‘enhansons’ (5′-GTGGAATGT-3′). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
产品来源
洱畔科技实验室
