Anti-DDB1 antibody
产品特性
| Product Cat#: | AB-06-1336 |
| Product type: | Primary antibody |
| Antigen: | DDB1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-1:200); Immunoprecipitation (1:20-1:50); Immunocytochemistry (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JU32-35) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Damage specific DNA binding protein 1 antibody |
| Damage-specific DNA-binding protein 1 antibody | |
| DDB 1 antibody | |
| DDB p127 subunit antibody | |
| Ddb1 antibody | |
| DDB1_HUMAN antibody | |
| DDBa antibody | |
| DNA damage binding protein 1 antibody | |
| DNA damage-binding protein 1 antibody | |
| DNA damage-binding protein a antibody | |
| HBV X-associated protein 1 antibody | |
| UV damaged DNA binding factor antibody | |
| UV damaged DNA binding protein 1 antibody | |
| UV DDB 1 antibody | |
| UV DDB1 antibody | |
| UV-damaged DNA-binding factor antibody | |
| UV-damaged DNA-binding protein 1 antibody | |
| UV-DDB 1 antibody | |
| X associated protein 1 antibody | |
| XAP 1 antibody | |
| XAP-1 antibody | |
| XAP1 antibody | |
| Xeroderma pigmentosum group E complementing protein antibody | |
| Xeroderma pigmentosum group E-complementing protein antibody | |
| XPCe antibody | |
| XPE antibody | |
| XPE BF antibody | |
| XPE binding factor antibody | |
| XPE-BF antibody | |
| XPE-binding factor antibody |
靶标信息
Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage.
产品来源
洱畔科技实验室
