Rat High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma ELISA kit
Specifications
| Product Cat#: | EK-07-0554 |
| Product name: | Rat High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma ELISA kit |
| Target Name: | FCER1G |
| Species Reactivity: | Rat |
| Product Size: | 48/96 Tests |
| Sensitivity: | 0.17 μg/ml |
| Assay range: | 2.5-50 μg/ml |
| Assay Time: | 90 minutes |
| Platform: | Colorimetric Microplate Reader |
| Conjugate: | HRP |
| ELISA Type: | Competitive ELISA |
| Detection Method: | Colorimetric |
| Storage temperature: | Store at 2-8°C |
| Stability: | Stable within the expiration date under suggested storage conditions |
| Shipping condition: | Wet ice |
| Kit Contents: | Microtiter plate (1x), Enzyme conjugate (1 vial), Standard samples (6 vials), |
| Substrates (A & B, 2 vials), Stop solution (1 vial), Wash Solution (100x, 1 vial), | |
| Balance solution (1 vial), Instruction (1 copy) | |
| Other Names of Target: | Gamma Polypeptide; Fc Receptor Gamma Chain; Fc-epsilon RI-gamma; FCER1G; FceRI gamma; FCRG; FcRgamma; High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma; IgE Fc Receptor Subunit Gamma; Immunoglobulin E Receptor High Affinity Gamma Chain |
Target information
IgE Fc Receptor I binds to the Fc region of immunoglobulins epsilon chain with high affinity, and is responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamines, responsible for the manifestations of allergy. IgE Fc Receptor I also induces the secretion of important lymphokines, effectors of the hypersensitivity response. It is a tetramer of a heavily glycosylated alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chains from Fc epsilon RI are also subunits of other Fc receptors. The gamma subunit is thought to be functionally significant in allowing the IgE Fc receptor to reach the cell surface. The cytoplasmic domains of the beta and gamma subunits each contain a conserved consesus sequence, ITAM, (immunoreceptor tyrosine activation motif). Phosphorylation of a pair of conserved tyrosine residues within this motif is required for signal transduction in mast cells and other hemopoietic cell types.
Provider
Erpantech Laboratory