IL-18 Polyclonal antibody
Specifications
| Product Cat#: | 10663-1-AP |
| Product type: | Primary antibody |
| Antigen: | IL-18 |
| Immunogen: | IL-18 fusion protein Ag1063 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | FC, IF/ICC, IHC, IP, WB, ELISA |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Concentration: | 750 μg/ml |
| Purity: | Antigen affinity purification |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Iboctadekin, IFN gamma inducing factor, IGIF, IL 1 gamma, IL 18, IL 1g, IL18, IL-18, IL1F4, Interleukin 1 gamma, Interleukin 18, Mature IL18, pre IL18, Pre-IL18 |
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Target information
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850).
Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714).
Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744).
Provider
Erpantech Laboratory