Human Matrix Metalloproteinase 2 ELISA kit
Specifications
| Product Cat#: | EK-07-0222 |
| Product name: | Human Matrix Metalloproteinase 2 ELISA kit |
| Target Name: | MMP 2 |
| Species Reactivity: | Human |
| Product Size: | 48/96 Tests |
| Sensitivity: | 0.17 ng/mL |
| Assay range: | 2.5-50 ng/mL |
| Assay Time: | 90 minutes |
| Platform: | Colorimetric Microplate Reader |
| Conjugate: | HRP |
| ELISA Type: | Competitive ELISA |
| Detection Method: | Colorimetric |
| Storage temperature: | Store at 2-8°C |
| Stability: | Stable within the expiration date under suggested storage conditions |
| Shipping condition: | Wet ice |
| Kit Contents: | Microtiter plate ( 1x ), Enzyme conjugate ( 1 vial ), Standard samples ( 6 vials ), |
| Substrates ( A & B, 2 vials ), Stop solution ( 1 vial ), Wash Solution ( 100x, 1 vial ), | |
| Balance solution ( 1 vial ), Instruction ( 1 copy ) | |
| Other Names of Target: | 72 kDa Gelatinase; 72kD type IV collagenase; CLG 4; CLG 4A; Collagenase Type 4 Alpha; Collagenase Type IV A; Gelatinase A; Gelatinase Alpha; Gelatinase Neutrophil; Matrix Metallopeptidase 2 Gelatinase A 72kDa Gelatinase 72kDa Type IV collagenase; Matrix Metalloproteinase 2 (gelatinase A, 72kDa Gelatinase, 72kDa type IV collagenase); Matrix Metalloproteinase 2; Matrix Metalloproteinase II; MMP II; MONA; Neutrophil Gelatinase; TBE 1 |
Target information
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Provider
Erpantech Laboratory
