Human Dickkopf Related Protein 1 ELISA kit
Specifications
| Product Cat#: | EK-07-0379 |
| Product name: | Human Dickkopf Related Protein 1 ELISA kit |
| Target Name: | DKK1 |
| Species Reactivity: | Human |
| Product Size: | 48/96 Tests |
| Sensitivity: | 16.5 pg/mL |
| Assay range: | 250-5000 pg/mL |
| Assay Time: | 90 minutes |
| Platform: | Colorimetric Microplate Reader |
| Conjugate: | HRP |
| ELISA Type: | Competitive ELISA |
| Detection Method: | Colorimetric |
| Storage temperature: | Store at 2-8°C |
| Stability: | Stable within the expiration date under suggested storage conditions |
| Shipping condition: | Wet ice |
| Kit Contents: | Microtiter plate (1x), Enzyme conjugate (1 vial), Standard samples (6 vials), |
| Substrates (A & B, 2 vials), Stop solution (1 vial), Wash Solution (100x, 1 vial), | |
| Balance solution (1 vial), Instruction (1 copy) | |
| Other Names of Target: | Dickkopf 1; Dickkopf 1 like; Dickkopf homolog 1; Dickkopf related protein 1; hDkk1; SK |
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Target information
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Provider
Erpantech Laboratory
