Human Cystic Fibrosis Transmembrane Conductance Regulator ELISA Kit
Specifications
Product Cat#:
EK-07-0093
Product name:
Human Cystic Fibrosis Transmembrane Conductance Regulator ELISA Kit
Target Name:
CFTR
Species Reactivity:
Human
Product Size:
48/96 Tests
Sensitivity:
0.09 ng/mL
Assay range:
0.5-10 ng/mL
Assay Time:
90 minutes
Platform:
Colorimetric Microplate Reader
Conjugate:
HRP
ELISA Type:
Competitive ELISA
Detection Method:
Colorimetric
Storage temperature:
Store at 2-8°C
Stability:
Stable within the expiration date under suggested storage conditions
Shipping condition:
Wet ice
Kit Contents:
Microtiter plate (1x), Enzyme conjugate (1 vial), Standard samples (6 vials),
Substrates (A & B, 2 vials), Stop solution (1 vial), Wash Solution (100x, 1 vial),
Balance solution (1 vial), Instruction (1 copy)
Other Names of Target:
ABC35; ABCC7; ATP binding cassette sub family C member 7; ATP Binding Cassette Superfamily C Member 7; ATP binding cassette transporter sub family C member 7; cAMP dependent chloride channel; CF; CFTR/MRP; Channel conductance controlling ATPase; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7; ATP-binding cassette sub-family C member 7; cAMP-dependent chloride channel; CFTR; CFTR_HUMAN; Channel conductance-controlling ATPase; Cystic Fibrosis Transmembrane Regulator; Cystic Fibrosis Transmembrane Regulator; dJ760C5.1; MRP7; TNR CFTR.
Target information
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters . Plays an important role in airway fluid homeostasis . Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens . Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 . Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Provider
Erpantech Laboratory
