Anti-YB1 antibody
Specifications
| Product Cat#: | AB-06-5064 |
| Product type: | Primary antibody |
| Antigen: | YB1 |
| Immunogen: | Synthetic peptide within human YBOX1 aa 302-355. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry-Paraffin (1:50-1:200); Immunocytochemistry (1:50-1:200); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.2% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | BP 8 antibody |
| CBF-A antibody | |
| CCAAT binding transcription factor I subunit A antibody | |
| CCAAT-binding transcription factor I subunit A antibody | |
| CSDA2 antibody | |
| CSDB antibody | |
| DBPB antibody | |
| DNA binding protein B antibody | |
| DNA-binding protein B antibody | |
| EFI-A antibody | |
| Enhancer factor I subunit A antibody | |
| MDR NF1 antibody | |
| MGC104858 antibody | |
| MGC110976 antibody | |
| MGC117250 antibody | |
| NSEP 1 antibody | |
| NSEP1 antibody | |
| Nuclease sensitive element binding protein 1 antibody | |
| Nuclease-sensitive element-binding protein 1 antibody | |
| p50 antibody | |
| Q15905 antibody | |
| Y-box binding protein 1 antibody | |
| Y-box transcription factor antibody | |
| Y-box-binding protein 1 antibody | |
| YB 1 antibody | |
| YB-1 antibody | |
| YBOX1_HUMAN antibody | |
| YBX 1 antibody | |
| ybx1 antibody |
Target information
DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969).
Predominantly acts as a RNA-binding protein: binds preferentially to the 5′-[CU]CUGCG-3′ RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969).
Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969).
Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303).
Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity).
Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095).
Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095).
Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925).
Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611).
Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ‘Lys-6’ and ‘Lys-7′ (PubMed:18809583).
Binds to promoters that contain a Y-box (5′-CTGATTGGCCAA-3’), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583).
Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551).
Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551).
The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673).
Gallery
Provider
Erpantech Laboratory
