Anti-YAP1 antibody
Specifications
| Product cat: | AB-06-4676 |
| Product type: | Primary antibody |
| Antigen: | YAP1 |
| Immunogen: | Amino acids 294-323 within an internal region of YAP of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:900-1:2400); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (3G1) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 65 kDa Yes associated protein antibody |
| 65 kDa Yes-associated protein antibody | |
| COB1 antibody | |
| YAp 1 antibody | |
| YAP 65 antibody | |
| YAP antibody | |
| YAP1 antibody | |
| YAP1_HUMAN antibody | |
| YAP2 antibody | |
| YAP65 antibody | |
| yes -associated protein delta antibody | |
| Yes associated protein 1 65kDa antibody | |
| Yes associated protein 1 antibody | |
| Yes associated protein 2 antibody | |
| yes associated protein beta antibody | |
| YKI antibody | |
| Yorkie homolog antibody |
Target information
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
Isoform 2: Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Provider
Erpantech Laboratory
