Anti-xCT antibody
Specifications
| Product Cat#: | AB-06-4867 |
| Product type: | Primary antibody |
| Antigen: | xCT |
| Immunogen: | 293 cell line overexpressing SLC7A11. |
| Species immunized: | Mouse |
| Isotype: | IgG2b |
| Applications: | Immunohistochemistry-Paraffin (1:200); Western Blot (1:500); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:100) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal, A7C6 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.05% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | Amino acid transport system xc xCT antibody antibody |
| Amino acid transport system xc- antibody | |
| Calcium channel blocker resistance protein CCBR1 antibody | |
| Calcium channel blocker resistance protein CCBR1 antibody antibody | |
| CCBR1 antibody | |
| Cysteine/glutamate transporter antibody antibody | |
| Cystine/glutamate transporter antibody | |
| OTTHUMP00000164578 antibody | |
| SLC7A11 antibody | |
| Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody | |
| solute carrier family 7 antibody | |
| Solute carrier family 7 member 11 antibody | |
| Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody | |
| SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN antibody | |
| xCT antibody | |
| XCT_HUMAN antibody |
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Target information
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Provider
Erpantech Laboratory