Anti-WNK4 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | WNK4 |
| Immunogen: | KLH conjugated synthetic peptide derived from human WNK4 351-450/1243 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot(1:450-1:2000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 50% glycerol, 0.03% Proclin |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | PHA 2B |
| PHA2B | |
| PRKWNK 4 | |
| PRKWNK4 | |
| Protein kinase lysine deficient 4 | |
| Protein kinase with no lysine 4 | |
| Serine/threonine protein kinase WNK4 | |
| WNK lysine deficient protein kinase 4 |
Target information
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K+ channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Provider
Erpantech Laboratory
