Anti-WDR41 Mouse Monoclonal antibody
Specifications
| Product Cat#: | AB-06-5094 |
| Product type: | Primary antibody |
| Antigen: | WDR41 |
| Immunogen: | Recombinant protein within human aa 231-430/459. |
| Predicted molecular weight: | 52 kDa |
| Observed molecular weight: | 52 kDa |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:500-1:2000); Immunocytochemistry/Immunofluorescence (1:100-1:200) |
| Reactivity: | Human, Rat |
| Clonality (clone number): | Monoclonal, A9C10 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH 7.4), 0.1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | FLJ10904 antibody |
| MSTP048 antibody | |
| WD repeat domain 41 antibody | |
| WD repeat protein 41 antibody | |
| WD repeat-containing protein 41 antibody | |
| WDR 41 antibody | |
| WDR41 antibody | |
| WDR41_HUMAN antibody |
Target information
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531).
The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069).
As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654).
The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).
Provider
Erpantech Laboratory
