Anti-VGluT1 Mouse Monoclonal antibody

Target information

Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226).
At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).
The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H+-ATPase across the synaptic vesicle membrane (By similarity).
In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity).
Moreover, may function as a K+/H+ antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity).
The vesicular K+/H+ antiport activity is electroneutral (By similarity).
At the plasma membrane, following exocytosis, functions as a symporter of Na+ and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226).
The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity).
Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity).