Anti-VAMP8 antibody
Specifications
| Product Cat#: | AB-06-4572 |
| Product type: | Primary antibody |
| Antigen: | VAMP8 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:900-1:2000); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:40-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JF0963) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA;40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | EDB antibody |
| Endobrevin antibody | |
| VAMP 8 antibody | |
| VAMP-8 antibody | |
| VAMP8 antibody | |
| VAMP8_HUMAN antibody | |
| Vesicle associated membrane protein 8 antibody | |
| Vesicle-associated membrane protein 8 antibody |
Target information
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets . Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).
Provider
Erpantech Laboratory