Anti-USP36 antibody
Specifications
| Product Cat#: | AB-06-4561 |
| Product type: | Primary antibody |
| Antigen: | USP36 |
| Immunogen: | Peptide |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry (1:40-1:200); Immunocytochemistry (1:40-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 0.5% BSA, 50% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Deubiquitinating enzyme 1 antibody |
| Deubiquitinating enzyme 36 antibody | |
| DUB1 antibody | |
| FLJ12851 antibody | |
| KIAA1453 antibody | |
| Ubiquitin carboxyl-terminal hydrolase 36 antibody | |
| Ubiquitin specific peptidase 36 antibody | |
| Ubiquitin specific processing protease 36 antibody | |
| Ubiquitin thioesterase 36 antibody | |
| Ubiquitin thiolesterase 36 antibody | |
| Ubiquitin-specific-processing protease 36 antibody | |
| UBP36_HUMAN antibody | |
| Usp36 antibody |
Target information
Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 ‘Lys-4’ trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm . Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
Provider
Erpantech Laboratory