Anti-USP10 antibody
Specifications
| Product Cat#: | AB-06-4551 |
| Product type: | Primary antibody |
| Antigen: | USP10 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:40-1:200); Immunocytochemistry (1:40-1:200); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JU32-62) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Deubiquitinating enzyme 10 antibody |
| KIAA0190 antibody | |
| MGC124997 antibody | |
| MGC2621 antibody | |
| Ubiquitin carboxyl terminal hydrolase 10 antibody | |
| Ubiquitin carboxyl-terminal hydrolase 10 antibody | |
| Ubiquitin specific peptidase 10 antibody | |
| Ubiquitin specific processing protease 10 antibody | |
| Ubiquitin specific protease 10 antibody | |
| Ubiquitin thioesterase 10 antibody | |
| Ubiquitin thiolesterase 10 antibody | |
| Ubiquitin-specific-processing protease 10 antibody | |
| UBP10_HUMAN antibody | |
| UBPO antibody | |
| USP 10 antibody | |
| USP10 antibody |
Target information
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage . Deubiquitinates TBX21 leading to its stabilization.
Provider
Erpantech Laboratory
