Anti-ULK2 antibody
Specifications
| Product Cat#: | AB-06-4540 |
| Product type: | Primary antibody |
| Antigen: | ULK2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:1000); Flow Cytometry (1:80-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ATG1B antibody |
| KIAA0623 antibody | |
| Serine/threonine protein kinase ULK2 antibody | |
| Serine/threonine-protein kinase ULK2 antibody | |
| ULK2 antibody | |
| ULK2_HUMAN antibody | |
| Unc 51 (C. elegans) like kinase 2 antibody | |
| Unc 51 like autophagy activating kinase 2 antibody | |
| Unc 51 like kinase 2 antibody | |
| Unc-51-like kinase 2 antibody | |
| Unc51.2 antibody |
Target information
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Provider
Erpantech Laboratory