Anti-TWIST1 Mouse Monoclonal Antibody
Specifications
| Product Cat#: | AB-06-5067 |
| Product type: | Primary antibody |
| Antigen: | TWIST1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000), Immunocytochemistry (1:40-1:200), Immunohistochemistry-Paraffin (1:100-500), Flow Cytometry (1:100-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal, E6-F4 |
| Form: | Liquid |
| Buffer: | PBS with 0.05% sodium azide, pH 7.3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | ACS3 antibody |
| B-HLH DNA binding protein antibody | |
| bHLHa38 antibody | |
| BPES2 antibody | |
| BPES3 antibody | |
| Class A basic helix-loop-helix protein 38 antibody | |
| CRS antibody | |
| CRS1 antibody | |
| CSO antibody | |
| H-twist antibody | |
| OTTHUMP00000116043 antibody | |
| SCS antibody | |
| Twist basic helix loop helix transcription factor 1 antibody | |
| Twist family bHLH transcription factor 1 antibody | |
| Twist homolog 1 (Drosophila) antibody | |
| Twist homolog 1 antibody | |
| TWIST homolog of drosophila antibody | |
| Twist related protein 1 antibody | |
| Twist-related protein 1 antibody | |
| TWIST1 antibody | |
| TWST1_HUMAN antibody |
Target information
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
Provider
Erpantech Laboratory
