Anti-Twist antibody
Specifications
| Product Cat#: | AB-06-4496 |
| Product type: | Primary antibody |
| Antigen: | Twist |
| Immunogen: | A recombinant protein corresponding to a region near the C-terminus of twist of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:50-1:1000); Immunoprecipitation (1-2 μg per 100-450 μg of total protein(1 ml of cell lysate)); Flow Cytometry (1.5 μg per 1 x 106 cells); Immunofluorescence (1:40-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (1G3) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ACS3 antibody |
| B-HLH DNA binding protein antibody | |
| BHLHa38 antibody | |
| BPES2 antibody | |
| BPES3 antibody |
Target information
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
Provider
Erpantech Laboratory
