Anti-TTC8 antibody
Specifications
| Product Cat#: | AB-06-4483 |
| Product type: | Primary antibody |
| Antigen: | TTC8 |
| Immunogen: | KLH conjugated synthetic peptide derived from human BBS8 251-330/541 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800); Flow Cytometry (0.25ug/test) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH 7.4), 1% BSA, 50% glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Bardet Biedl syndrome 8 protein |
| Bardet Biedl syndrome type 8 | |
| Bardet-Biedl syndrome 8 protein | |
| BBS8 | |
| Tetratricopeptide repeat domain 8 | |
| Tetratricopeptide repeat protein 8 | |
| TPR repeat protein 8 | |
| TTC 8 | |
| Ttc8 |
Target information
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Provider
Erpantech Laboratory
