Anti-TRPV6 antibody
Specifications
| Product Cat#: | AB-06-4853 |
| Product type: | Primary antibody |
| Antigen: | TRPV6 |
| Immunogen: | Synthesized peptide derived from part region of human protein. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality: | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.3), 50% Glycerol, 0.02% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immoungen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | Transient Receptor Potential Cation Channel Subfamily V Member 6 |
| Epithelial Calcium Channel 2 | |
| ECAC2 | |
| CaT1 | |
| Calcium Transport Protein 1 | |
| Transient Receptor Potential Cation Channel, Subfamily V, Member 6 | |
| Epithelial Apical Membrane Calcium Transporter/Channel CaT1 | |
| Alu-Binding Protein With Zinc Finger Domain | |
| Calcium Transporter-Like Protein | |
| HSA277909 | |
| CaT-Like | |
| ABP/ZF | |
| HRPTTN | |
| LP6728 | |
| TrpV6 | |
| CaT-L | |
| ECaC2 | |
| CAT1 | |
| CATL | |
| ZFAB |
Target information
Calcium selective cation channel that mediates Ca2+ uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289).
Important for normal Ca2+ ion homeostasis in the body, including bone and skin (By similarity).
The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369).
Inactivation includes both a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Provider
Erpantech Laboratory
