Anti-TRAF6 antibody
Specifications
| Product Cat#: | AB-06-4420 |
| Product type: | Primary antibody |
| Antigen: | TRAF6 |
| Immunogen: | Peptide |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunocytochemistry (1:50-1:200); Immunohistochemistry |
| Reactivity: | Human, Mouse, Rat, Hybrid fish (crucian-carp) |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | E3 ubiquitin-protein ligase TRAF6 antibody |
| Interleukin 1 signal transducer antibody | |
| Interleukin-1 signal transducer antibody | |
| MGC 3310 antibody | |
| MGC:3310 antibody | |
| MGC3310 antibody | |
| OTTHUMP00000232772 antibody | |
| OTTHUMP00000232773 antibody | |
| RING finger protein 85 antibody | |
| RNF 85 antibody | |
| RNF85 antibody | |
| TNF receptor associated factor 6 antibody | |
| TNF receptor-associated factor 6 antibody | |
| TNF receptor-associated factor 6, E3 ubiquitin protein ligase antibody | |
| TRAF 6 antibody | |
| Traf6 antibody | |
| TRAF6_HUMAN antibody |
Target information
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ‘Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
Provider
Erpantech Laboratory
