Anti-TPMT antibody
Specifications
| Product Cat#: | AB-06-4883 |
| Product type: | Primary antibody |
| Antigen: | TPMT |
| Immunogen: | Synthetic peptide within human TPMT aa 101-150/245. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400); Immunohistochemistry-Paraffin (1:50-1:100); Flow Cytometry (1:400-1:1000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JE64-09 |
| Form: | Liquid |
| Buffer: | 1*TBS buffer (pH7.4), 0.05% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | HGNC:12014 antibody |
| S adenosyl L methionine thiopurine S methyltransferase antibody | |
| Thiopurine methyltransferase antibody | |
| Thiopurine S methyltransferase antibody | |
| Thiopurine S-methyltransferase antibody | |
| TPMT antibody | |
| TPMT_HUMAN antibody |
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Target information
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Provider
Erpantech Laboratory
