Anti-TNFA antibody
Specifications
| Product Cat#: | AB-07-3899 |
| Product type: | Primary antibody |
| Antigen: | TNFA |
| Immunogen: | A synthetic peptide derived from human TNFA . The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry (1:50-1:100); Immunofluorescence (1:100-1:500); ELISA (1:10000) |
| Reactivity: | Human, Mouse and Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Protein name Tumor necrosis factor [Precursor], TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, Tumor necrosis factor, membrane form, Tumor necrosis factor, soluble form, TNF, TNFA, TNFSF2 |
Target information
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176).
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Provider
Erpantech Laboratory
