Anti-TNF Receptor I antibody
Specifications
| Product Cat#: | AB-07-3897 |
| Product type: | Primary antibody |
| Antigen: | TNF Receptor I |
| Immunogen: | A synthetic peptide derived from human TNF Receptor I. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry (1:50-1:100); ELISA (1:1000) |
| Reactivity: | Human, Mouse and Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CD120a, TBPI, TNF-RI, TNFAR, TNFR1, TNFRSF1A, TNR1A, p55, p60, tumor necrosis factor receptor superfamily member 1A |
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Target information
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Provider
Erpantech Laboratory
