Anti-TNF alpha antibody
Specifications
| Product Cat#: | AB-06-4390 |
| Product type: | Primary antibody |
| Antigen: | TNF alpha |
| Immunogen: | Peptide |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); ELISA ( 1:8000-20000) |
| Reactivity: | Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | APC1 antibody |
| APC1 protein antibody | |
| Cachectin antibody | |
| DIF antibody | |
| Differentiation inducing factor antibody | |
| Macrophage cytotoxic factor antibody | |
| Tnf antibody | |
| TNF superfamily, member 2 antibody | |
| TNF, macrophage derived antibody | |
| TNF, monocyte derived antibody | |
| TNF-a antibody | |
| TNF-alpha antibody | |
| TNFA antibody | |
| TNFA_HUMAN antibody | |
| TNFSF2 antibody | |
| Tumor necrosis factor alpha antibody | |
| Tumor necrosis factor antibody | |
| Tumor necrosis factor ligand superfamily member 2 antibody | |
| Tumor Necrosis Factor, Membrane Form antibody | |
| Tumor necrosis factor, soluble form antibody |
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Target information
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.
Provider
Erpantech Laboratory
