Anti-TMEPAI antibody
Specifications
| Product Cat#: | AB-06-4387 |
| Product type: | Primary antibody |
| Antigen: | TMEPAI |
| Immunogen: | KLH conjugated synthetic peptide derived from human TMEPAI 21-120/287 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH 7.4), 1% BSA, 50% glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | PMEPA_HUMAN |
| PMEPA1 | |
| Prostate transmembrane protein, androgen induced 1 | |
| Solid tumor associated 1 protein | |
| Solid tumor-associated 1 protein | |
| STAG1 | |
| Transmembrane prostate androgen induced protein | |
| Transmembrane prostate androgen-induced protein |
Target information
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
Provider
Erpantech Laboratory
