Anti-TMEM173 antibody
Specifications
| Product Cat#: | AB-06-4380 |
| Product type: | Primary antibody |
| Antigen: | TMEM173 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:20-1:50); Immunofluorescence |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Endoplasmic reticulum IFN stimulator antibody |
| Endoplasmic reticulum interferon stimulator antibody | |
| ERIS antibody | |
| FLJ38577 antibody | |
| HMITA antibody | |
| HSTING antibody | |
| Mediator of IRF3 activation antibody | |
| MITA antibody | |
| Mitochondrial mediator of IRF3 activation antibody | |
| MPYS antibody | |
| N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody | |
| NET23 antibody | |
| Stimulator of interferon genes antibody | |
| Stimulator of interferon genes protein antibody | |
| STING antibody | |
| TM173_HUMAN antibody | |
| Tmem173 antibody |
Target information
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of c-di-GMP or cGAMP, TMEM173/STING oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state. In addition to promote the production of type I interferons, plays a direct role in autophagy.
Provider
Erpantech Laboratory