Anti-TDP43 antibody
Specifications
| Product Cat#: | AB-06-4296 |
| Product type: | Primary antibody |
| Antigen: | TDP43 |
| Immunogen: | Synthetic peptide within human TDP43 aa 350-390. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:5000); Immunohistochemistry-Paraffin (1:40-1:200); Flow Cytometry (1:40-1:100); Immunocytochemistry/Immunofluorescence (1:100-1:500); Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat, Zebrafish |
| Clonality (clone number): | Monoclonal (JM51-10) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.05% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ALS10 antibody |
| OTTHUMP00000002171 antibody | |
| OTTHUMP00000002172 antibody | |
| OTTHUMP00000002173 antibody | |
| TADBP_HUMAN antibody | |
| TAR DNA binding protein 43 antibody | |
| TAR DNA binding protein antibody | |
| TAR DNA-binding protein 43 antibody | |
| TARDBP antibody | |
| TDP 43 antibody | |
| TDP-43 antibody | |
| TDP43 antibody |
Target information
RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3’UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3’UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival.
Provider
Erpantech Laboratory
