Anti-Syntenin antibody
Specifications
| Product Cat#: | AB-06-4260 |
| Product type: | Primary antibody |
| Antigen: | Syntenin |
| Immunogen: | Recombinant protein within human Syntenin aa 1-200. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry (1:80-1:200); Immunocytochemistry (1:80-1:200); Flow Cytometry (1:80-1:200); Immunoprecipitation (1:10-1:60); Immunofluorescence (1:80-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JE40-72) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | MDA-9 antibody |
| MDA9 antibody | |
| Melanoma differentiation-associated protein 9 antibody | |
| Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody | |
| Scaffold protein Pbp1 antibody | |
| SDCB1_HUMAN antibody | |
| SDCBP antibody | |
| ST1 antibody | |
| SYCL antibody | |
| Syndecan binding protein (syntenin) antibody | |
| Syndecan binding protein 1 antibody | |
| Syndecan-binding protein 1 antibody | |
| Syntenin 1 antibody | |
| Syntenin-1 antibody | |
| TACIP18 antibody |
Target information
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis . Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis . Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types . In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) . May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway .
Provider
Erpantech Laboratory
