Anti-Syntaxin 1a antibody
Specifications
| Product Cat#: | AB-06-4782 |
| Product type: | Primary antibody |
| Antigen: | Syntaxin 1a |
| Immunogen: | Synthetic peptide within N-terminal Human Syntaxin 1a. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:50-200); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JE54-37 |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 50%Glycerol, 0.05% NaN3 |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | HPC 1 antibody |
| Neuron specific antigen HPC1 antibody | |
| Neuron-specific antigen HPC-1 antibody | |
| OTTHUMP00000174615 antibody | |
| OTTHUMP00000174616 antibody | |
| OTTHUMP00000174617 antibody | |
| OTTHUMP00000174618 antibody | |
| P35-1 antibody | |
| STX1 antibody | |
| STX1A antibody | |
| STX1A_HUMAN antibody | |
| SYN1A antibody | |
| Syntaxin 1A (brain) antibody | |
| Syntaxin 1A brain antibody | |
| Syntaxin-1A antibody |
Target information
Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1).
Provider
Erpantech Laboratory
