Anti-Survivin antibody
Specifications
| Product Cat#: | AB-06-4241 |
| Product type: | Primary antibody |
| Antigen: | Survivin |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunofluorescence; Western Blot (1:1000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:200); Flow Cytometry (1:40-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (SP07-06) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | API4 antibody |
| Apoptosis inhibitor 4 antibody | |
| Apoptosis inhibitor survivin antibody | |
| Apoptosis inhibitor4 antibody | |
| Baculoviral IAP repeat containing 5 antibody | |
| Baculoviral IAP repeat containing protein 5 antibody | |
| Baculoviral IAP repeat-containing protein 5 antibody | |
| BIRC 5 antibody | |
| BIRC5 antibody | |
| BIRC5_HUMAN antibody | |
| IAP4 antibody | |
| Survivin variant 3 alpha antibody | |
| SVV antibody | |
| TIAP antibody |
Target information
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis . Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules . Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at ‘Thr-3’ (H3pT3) during mitosis . The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase . The acetylated form represses STAT3 transactivation of target gene promoters . May play a role in neoplasia . Inhibitor of CASP3 and CASP7 . Isoform 2 and isoform 3 do not appear to play vital roles in mitosis . Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform .
Provider
Erpantech Laboratory
