Anti-SUPT16H antibody
Specifications
| Product Cat#: | AB-06-4238 |
| Product type: | Primary antibody |
| Antigen: | SUPT16H |
| Immunogen: | KLH conjugated synthetic peptide derived from human SUPT16H/CDC68 601-700/1047 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CDC68 |
| Chromatin specific transcription elongation factor 140 kDa subunit | |
| Chromatin-specific transcription elongation factor 140 kDa subunit | |
| Facilitates chromatin transcription complex subunit SPT16 | |
| FACT 140 kDa subunit | |
| FACT | |
| FACT complex subunit SPT16 | |
| FACTP140 | |
| FLJ10857 | |
| FLJ14010 | |
| HSPT16 | |
| SP16H_HUMAN | |
| Suppressor of Ty 16 homolog |
Target information
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of ‘Ser-392’ of p53/TP53 via its association with CK2 (casein kinase II).
Provider
Erpantech Laboratory
