Anti-STAT2 antibody
Specifications
| Product Cat#: | AB-06-4202 |
| Product type: | Primary antibody |
| Antigen: | STAT2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:1000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:200) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (JF0884) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Homo sapiens interferon alpha induced transcriptional activator antibody |
| interferon alpha induced transcriptional activator antibody | |
| ISGF 3 antibody | |
| ISGF3 antibody | |
| MGC59816 antibody | |
| P113 antibody | |
| Signal transducer and activator of transcription 2 113kD antibody | |
| Signal transducer and activator of transcription 2 antibody | |
| STAT113 antibody | |
| Stat2 antibody | |
| STAT2_HUMAN antibody |
Target information
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state . Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at ‘Ser-616’ and ‘Ser-637’ which activate and inactivate the GTPase activity of DNM1L respectively .
Provider
Erpantech Laboratory
