Anti-SP1 antibody
Specifications
| Product Cat#: | AB-06-4160 |
| Product type: | Primary antibody |
| Antigen: | SP1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunofluorescence; Western Blot (1:800-1:2000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:200-1:500) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JF0950) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | SP 1 antibody |
| SP1 antibody | |
| Sp1 transcription factor antibody | |
| SP1_HUMAN antibody | |
| Specificity protein 1 antibody | |
| Transcription factor Sp1 antibody | |
| TSFP 1 antibody | |
| TSFP1 antibody |
Target information
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 . Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
Provider
Erpantech Laboratory