Anti-SNAI2 antibody
Specifications
| Product cat: | AB-06-4133 |
| Product type: | Primary antibody |
| Antigen: | SNAI2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:900-1:2400); Immunohistochemistry (1:90-1:260); Immunocytochemistry (1:100-1:250); Flow Cytometry (1:70-1:260) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (D5-B6) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | MGC10182 antibody |
| Neural crest transcription factor Slug antibody | |
| Protein snail homolog 2 antibody | |
| Slug (chicken homolog) zinc finger protein antibody | |
| Slug homolog zinc finger protein antibody | |
| Slug zinc finger protein antibody | |
| SLUGH antibody | |
| SLUGH 1 antibody | |
| SLUGH1 antibody | |
| SNAI 2 antibody | |
| Snai2 antibody | |
| SNAI2_HUMAN antibody | |
| Snail 2 antibody | |
| Snail homolog 2 antibody | |
| Snail2 antibody | |
| WS 2D antibody | |
| WS2D antibody | |
| Zinc finger protein SLUG antibody | |
| Zinc finger protein SNAI2 antibody |
Target information
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
Provider
Erpantech Laboratory
