Anti-SMAD6 antibody
Specifications
| Product Cat#: | AB-06-4121 |
| Product type: | Primary antibody |
| Antigen: | SMAD6 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot ( 1:800-1:1000 ) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal ( H6-H3 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | hSMAD6 Antibody |
| MAD Homolog 6 Antibody | |
| MADH6 Antibody | |
| MADH7 Antibody | |
| Mothers Against Decapentaplegic Homolog 6 Antibody | |
| Mothers Against DPP Homolog 6 Antibody | |
| SMAD 6 Antibody | |
| SMAD Family Member 6 Antibody | |
| SMAD Mothers Against DPP Homolog 6 Antibody | |
| Smad6 Antibody | |
| SMAD6_HUMAN Antibody |
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Target information
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Provider
Erpantech Laboratory
