Anti-Smad2 antibody
Specifications
| Product Cat#: | |
| Product type: | Primary antibody |
| Antigen: | Smad2 |
| Immunogen: | Peptide |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:800-1:1000 ); Immunoprecipitation ( 1-3 μg per 100-500 μg of total protein ( 1 ml of cell lysate ) );Immunofluorescence ( 1:40-1:500 ); Flow Cytometry ( 1:40-1:500 ) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal ( 4D3 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | hMAD 2 Antibody |
| hMAD 3 Antibody | |
| hSMAD2 Antibody | |
| hSMAD3 Antibody | |
| Mad Related Protein 2 Antibody | |
| MADH2 Antibody | |
| MADH3 Antibody | |
| MADR2Antibody | |
| Mothers Against DPP Homolog 2 Antibody | |
| Mothers Against DPP Homolog 3 Antibody | |
| Sma and Mad Related Protein 2 Antibody | |
| SMA and MAD Related Protein 3 Antibody | |
| SMAD 2 Antibody | |
| SMAD 3 Antibody | |
| SMAD Family Member 2 Antibody | |
| SMAD Family Member 3 Antibody | |
| smad2+3 Antibody | |
| smad2/3 Antibody |
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Target information
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Provider
Erpantech Laboratory