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Anti-SIRT6 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-4070
Anti-SIRT6 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-4070
Product type: Primary antibody
Antigen: SIRT6
Immunogen: Peptide
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot ( 1:800-1:2000 ); Immunohistochemistry ( 1:80-1:200 ); Flow Cytometry ( 1:40-1:100 )
Reactivity: Mouse, Rat and Human
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3.
Concentration: 1 mg/ml
Purity: Peptide affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: 2810449N18Rik Antibody
AI043036 Antibody
Mono ADP Ribosyltransferase Sirtuin 6 Antibody
NAD-dependent Protein Deacetylase Sirtuin-6 Antibody
Regulatory Protein SIR2Homolog 6 Antibody
Regulatory Protein SIR2 Homolog Antibody
SIR2 Like 6 Antibody
SIR2 Like Protein 6 Antibody
Sir2 Related Protein Type 6 Antibody
SIR2-like Protein 6 Antibody
SIR2L6Antibody
SIR6_HUMAN Antibody
SIRT 6 Antibody
SIRT6 Antibody
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 6 (S. cerevisiae) Antibody
Sirtuin 6 Antibody
Sirtuin type 6 Antibody
Sirtuin6 Antibody
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Target information

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.

Provider

Erpantech Laboratory

download

MSDS-AB-06-4070.pdf (124 downloads )