Anti-Sirp α1 antibody
Specifications
| Product Cat#: | AB-07-3728 |
| Product type: | Primary antibody |
| Antigen: | Sirp α1 |
| Immunogen: | A synthetic peptide derived from human Sirp α1. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500~1:3000); ELISA (1:20000); Immunohistochemistry (1:50~1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Bit, MFR, MYD-1 antigen, MYD1, Macrophage fusion receptor, PTPNS1, SHP substrate-1, SHPS-1, SHS1, SIRP, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, brain Ig-like molecule with tyrosine-based activation motifs, inhibitory receptor SHPS-1, p84, protein-tyrosi |
Target information
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Provider
Erpantech Laboratory
