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Anti-SF3B14 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-07-2106
Anti-SF3B14 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-07-2106
Product type: Primary antibody
Antigen: SF3B14
Immunogen: A synthetic peptide derived from C-terminal of human SF3B14.. The exact amino-acid sequence is proprietary.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:2500); ELISA (1:35000);
Reactivity: Human, Mouse
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodiumazide and 50% glycerol.
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: CGI-110; HSPC175; Ht006; PM14; Pre-mRNA branch site protein p14
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Target information

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for ‘A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PubMed:16432215). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215).

Provider

Erpantech Laboratory

download

MSDS-AB-07-2106.pdf (97 downloads )