Anti-SAMHD1 antibody
Specifications
| Product Cat#: | AB-06-3959 |
| Product type: | Primary antibody |
| Antigen: | SAMHD1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000); Immunocytochemistry (1:100-1:400); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:10-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal(JU56-04) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | CHBL2 antibody |
| DCIP antibody | |
| Dendritic cell derived IFNG induced protein antibody | |
| Dendritic cell-derived IFNG-induced protein antibody | |
| Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 antibody | |
| DNTPase antibody | |
| HD domain containing 1 antibody | |
| HDDC1 antibody | |
| Mg11 antibody | |
| Monocyte protein 5 antibody | |
| MOP 5 antibody | |
| MOP-5 antibody | |
| MOP5 antibody | |
| OTTHUMP00000030889 antibody | |
| SAM domain and HD domain 1 antibody | |
| SAM domain and HD domain containing protein 1 antibody | |
| SAM domain and HD domain-containing protein 1 antibody | |
| SAMH1_HUMAN antibody | |
| Samhd1 antibody | |
| SBBI88 antibody |
Target information
Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:22056990, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:23364794, PubMed:25038827, PubMed:26101257, PubMed:22056990, PubMed:24336198, PubMed:28229507, PubMed:26294762, PubMed:26431200). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:29610582, PubMed:24217394). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23602554, PubMed:23601106, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity).
Provider
Erpantech Laboratory