Anti-RYBP antibody
Specifications
| Product Cat#: | AB-06-4955 |
| Product type: | Primary antibody |
| Antigen: | RYBP |
| Immunogen: | Recombinant protein within Human RYBP aa 1-200/228. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | 2410018J24Rik antibody |
| AAP 1 antibody | |
| AAP1 antibody | |
| APAP 1 antibody | |
| APAP-1 antibody | |
| APAP1 antibody | |
| Apoptin associating protein 1 antibody | |
| Apoptin-associating protein 1 antibody | |
| cb337 antibody | |
| Death effector domain associated factor antibody | |
| Death effector domain-associated factor antibody | |
| Death effector domain-associated factor B antibody | |
| DED associated factor antibody | |
| DED-associated factor antibody | |
| DED-associated factor B antibody | |
| DEDAF antibody | |
| MGC62213 antibody | |
| RING1 and YY1 binding protein a antibody | |
| RING1 and YY1 binding protein antibody | |
| RING1 and YY1-binding protein antibody | |
| RING1 and YY1-binding protein B antibody | |
| Ring1 interactor RYBP antibody | |
| RYBP antibody | |
| RYBP_HUMAN antibody | |
| rybpa antibody | |
| wu:fi34f03 antibody | |
| YEAF 1 antibody | |
| YEAF1 antibody | |
| YY1 and E4TF1 associated factor 1 antibody | |
| YY1 and E4TF1-associated factor 1 antibody | |
| YY1- and E4TF1/GABP-associated factor 1 antibody | |
| zgc:153842 antibody |
Target information
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility (PubMed:25519132).
Component of a PRC1-like complex that mediates monoubiquitination of histone H2A ‘Lys-119’ on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A ‘Lys-119’ by recruiting the complex to target sites (By similarity).
Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711).
May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496).
May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439).
May bind to DNA (By similarity).
May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911).
Provider
Erpantech Laboratory
