Anti-RUNX2 antibody
Specifications
| Product Cat#: | AB-06-3937 |
| Product type: | Primary antibody |
| Antigen: | RUNX2 |
| Immunogen: | Synthetic peptide of C-terminal human RUNX2 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200); |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 50% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Acute myeloid leukemia 3 protein antibody |
| Alpha subunit 1 antibody | |
| AML3 antibody | |
| CBF alpha 1 antibody | |
| CBF-alpha-1 antibody | |
| CBFA1 antibody | |
| CCD antibody | |
| CCD1 antibody | |
| Cleidocranial dysplasia 1 antibody | |
| Core binding factor antibody | |
| Core binding factor runt domain alpha subunit 1 antibody | |
| Core binding factor subunit alpha 1 antibody | |
| Core-binding factor subunit alpha-1 antibody | |
| MGC120022 antibody | |
| MGC120023 antibody | |
| Oncogene AML 3 antibody | |
| Oncogene AML-3 antibody | |
| OSF 2 antibody | |
| OSF-2 antibody | |
| OSF2 antibody | |
| Osteoblast specific transcription factor 2 antibody | |
| Osteoblast-specific transcription factor 2 antibody | |
| OTTHUMP00000016533 antibody | |
| PEA2 alpha A antibody | |
| PEA2-alpha A antibody | |
| PEA2aA antibody | |
| PEBP2 alpha A antibody | |
| PEBP2-alpha A antibody | |
| PEBP2A1 antibody | |
| PEBP2A2 antibody | |
| PEBP2aA antibody | |
| PEBP2aA1 antibody | |
| Polyomavirus enhancer binding protein 2 alpha A subunit antibody | |
| Polyomavirus enhancer-binding protein 2 alpha A subunit antibody | |
| Runt domain antibody | |
| Runt related transcription factor 2 antibody | |
| Runt-related transcription factor 2 antibody | |
| RUNX2 antibody | |
| RUNX2_HUMAN antibody | |
| SL3 3 enhancer factor 1 alpha A subunit antibody | |
| SL3-3 enhancer factor 1 alpha A subunit antibody | |
| SL3/AKV core binding factor alpha A subunit antibody | |
| SL3/AKV core-binding factor alpha A subunit antibody |
Target information
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5′-PYGPYGGT-3′, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Provider
Erpantech Laboratory
