Anti-ROS1 antibody
Specifications
| Product Cat#: | AB-06-3915 |
| Product type: | Primary antibody |
| Antigen: | ROS1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human ROS 2231-2347/2347 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1ug/Test) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | ROS |
| Ros protein | |
| C ros | |
| C-ros | |
| C ros1 | |
| MCF3 | |
| Oncogene ROS | |
| OTTHUMP00000040389 | |
| Proto oncogene c ros 1 protein | |
| Proto oncogene tyrosine protein kinase ROS | |
| Proto oncogene tyrosine protein kinase ROS precursor | |
| Ros1 | |
| ROS1C | |
| Transmembrane tyrosine specific protein kinase | |
| V ros avian UR2 sarcoma virus oncogene homolog 1 | |
| V ros UR2 sarcoma virus oncogene homolog 1 | |
| ROS1_HUMAN | |
| Proto-oncogene tyrosine-protein kinase ROS | |
| Proto-oncogene c-Ros | |
| Proto-oncogene c-Ros-1 | |
| Receptor tyrosine kinase c-ros oncogene 1 |
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Target information
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Provider
Erpantech Laboratory
