Anti-ROCK2 antibody
Specifications
| Product Cat#: | AB-06-3908 |
| Product type: | Primary antibody |
| Antigen: | ROCK2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200); Western Blot (1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 50% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Coiled-coil-containing protein kinase 2 antibody |
| KIAA0619 antibody | |
| P164 ROCK 2 antibody | |
| P164 ROCK-2 antibody | |
| Rho associated coiled coil containing protein kinase 2 antibody | |
| Rho associated protein kinase 2 antibody | |
| Rho associated, coiled coil containing protein kinase II antibody | |
| Rho kinase 2 antibody | |
| Rho-associated antibody | |
| Rho-associated protein kinase 2 antibody | |
| ROCK 2 antibody | |
| Rock II antibody | |
| Rock2 antibody | |
| ROCK2_HUMAN antibody | |
| Rock2m antibody | |
| ROK alpha antibody | |
| ROKalpha antibody |
Target information
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
Provider
Erpantech Laboratory
