Anti-ROCK1 antibody
Specifications
| Product Cat#: | AB-06-3906 |
| Product type: | Primary antibody |
| Antigen: | ROCK1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200); Western Blot (1:1000-1:5000); Flow Cytometry (1:50-1:100); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (ST05-19) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Coiled-coil-containing protein kinase 1 antibody |
| Coiled-coil-containing protein kinase I antibody | |
| MGC131603 antibody | |
| MGC43611 antibody | |
| P160 Rhoassociated coiled coil-forming protein kinase antibody | |
| P160 ROCK-1 antibody | |
| P160 ROCK1 antibody | |
| P160ROCK antibody | |
| PRO0435 antibody | |
| Renal carcinoma antigen NY REN 35 antibody | |
| Renal carcinoma antigen NY-REN-35 antibody | |
| Rho associated coiled coil containing protein kinase 1 antibody | |
| Rho associated protein kinase 1 antibody | |
| Rho kinase antibody | |
| Rho-alpha kinase antibody | |
| Rho-associated antibody | |
| Rho-associated protein kinase 1 antibody | |
| ROCK I antibody | |
| ROCK-I antibody | |
| ROCK1 antibody | |
| ROCK1_HUMAN antibody | |
| Rok antibody | |
| Rokalpha antibody |
Target information
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
Provider
Erpantech Laboratory