Anti-RNF12 antibody
Specifications
| Product Cat#: | AB-06-3886 |
| Product type: | Primary antibody |
| Antigen: | RNF12 |
| Immunogen: | KLH conjugated synthetic peptide derived from human RNF12 525-624/624 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | RLIM |
| RING finger LIM domain-binding protein | |
| Ring finger protein 12 | |
| RNF12_HUMAN |
Target information
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Provider
Erpantech Laboratory
