Anti-RNF111 antibody
Specifications
| Product Cat#: | AB-06-4816 |
| Product type: | Primary antibody |
| Antigen: | RNF111 |
| Immunogen: | A synthetic peptide derived from human RNF111. The exact amino-acid sequence is 795-994 / 994. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:50-200) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS (pH7.4), 0.2% BSA, 50% glycerol and 0.05% sodium azide. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Non-conjugated |
| Alternative names: | BCA2 antibody |
| Breast cancer associated gene 2 antibody | |
| CL469780 antibody | |
| E3 ubiquitin-protein ligase RNF115 antibody | |
| Rabring 7 antibody | |
| RING finger protein 115 antibody | |
| RN115_HUMAN antibody | |
| RNF115 antibody | |
| Zinc finger protein 364 antibody | |
| ZNF364 antibody |
Target information
E3 ubiquitin-protein ligase (PubMed:26656854).
Required for mesoderm patterning during embryonic development (By similarity).
Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693).
Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693).
In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors ‘in use’ are degraded (By similarity).
Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695).
Associates with UBE2D2 as an E2 enzyme (PubMed:22411132).
Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493).
Catalyzes ‘Lys-63’-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493).
Mediates ubiquitination and degradation of sumoylated PML (By similarity).
The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
Provider
Erpantech Laboratory
